TXLNA
Description
The TXLNA (taxilin alpha) is a protein-coding gene located on chromosome 1.
Alpha-taxilin, also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF), is a protein encoded by the TXLNA gene. IL-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells. It induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. IL-14 is mainly produced by T cells and certain malignant B cells. In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β. The il14 locus is near the gene for LCK on chromosome 1 in humans.
May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
TXLNA is also known as IL-14, IL14, TXLN.
Associated Diseases
- hemoglobin D disease
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- delta-beta-thalassemia
- dominant beta-thalassemia
- hemoglobin E-beta-thalassemia syndrome
- hemoglobin C-beta-thalassemia syndrome
- alpha-thalassemia-myelodysplastic syndrome
- hemoglobin E disease
- hemoglobin H disease
- beta-thalassemia-X-linked thrombocytopenia syndrome
