TTTY13
The Intriguing World of TTTY13 Gene: Unraveling Its Functions and Implications
Description
The TTTY13 gene, located on the long arm of chromosome 19 (19q13.2), encodes a protein known as the testis-specific transcript, Y-linked 13 (TSPY13). This gene is exclusively found on the Y chromosome, which is responsible for male sex determination. The TSPY13 protein is primarily expressed in the testes, where it plays a crucial role in spermatogenesis, the process of sperm production.
Associated Diseases
Mutations or deletions in the TTTY13 gene have been linked to a rare condition called azoospermia, which is characterized by a complete absence of sperm in the semen. Azoospermia can result from various factors, including genetic abnormalities, hormonal imbalances, and acquired disorders. In some cases, mutations in the TTTY13 gene are identified as the underlying cause of non-obstructive azoospermia, a type of azoospermia that does not involve any physical blockage in the reproductive tract.
Did you Know ?
Research has shown that mutations in the TTTY13 gene account for approximately 2-5% of all cases of non-obstructive azoospermia. This statistic highlights the significant contribution of this gene to male infertility.
