TSSK6
Tssk6 Gene: A Comprehensive Guide
Description
The tssk6 gene, located on chromosome 12 in humans, encodes the tripartite motif-containing protein 6. This protein plays a crucial role in cellular signaling and is involved in various biological processes, including apoptosis, cell migration, and immune responses.
Tssk6 contains three main domains: an N-terminal tripartite motif (TRIM), a central coiled-coil domain, and a C-terminal domain with a proline-rich region. The TRIM domain facilitates protein-protein interactions, while the coiled-coil domain mediates protein dimerization.
Associated Diseases
Mutations in the tssk6 gene have been linked to several diseases, including:
- Cancers: Tssk6 has been implicated in the development of various cancers, such as breast cancer, lung cancer, and colon cancer. Mutations in the tssk6 gene can enhance cell proliferation, inhibit apoptosis, and promote tumor growth.
- Neurodegenerative disorders: Tssk6 is thought to play a role in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. Mutations in the tssk6 gene can impair neuronal function and contribute to neurological damage.
- Autoimmune diseases: Tssk6 has been associated with autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Mutations in the tssk6 gene can disrupt immune regulation, leading to excessive inflammation and tissue damage.
Did you Know ?
According to a recent study, mutations in the tssk6 gene are present in approximately 10% of breast cancer patients. These mutations are associated with a more aggressive disease course and a poorer prognosis.
