TRPV2
Description
The TRPV2 (transient receptor potential cation channel subfamily V member 2) is a protein-coding gene located on chromosome 17.
TRPV2, a member of the TRP channel family, is a non-specific cation channel that enables cell communication with the extracellular environment through ion transfer. It is primarily activated by noxious temperatures above 52 °C, unlike other members of the TRPV subfamily, such as TRPV1, which respond to vanilloids and lower temperatures. While initially characterized as a heat sensor, TRPV2 has broader roles in osmosensory and mechanosensory mechanisms, responding to various stimuli including hormones, growth factors, mechanical stretching, osmotic swelling, lysophospholipids, and cannabinoids. This versatile channel is expressed in various tissues, including neurons, motor neurons, the heart, and lungs, highlighting its importance in diverse cellular functions, such as contraction, cell proliferation, and cell death.
TRPV2 is also known as VRL, VRL-1, VRL1.
Associated Diseases
- Miyoshi myopathy
- cystic fibrosis
- isolated agammaglobulinemia
- mannose-binding lectin deficiency
- cancer
- hyper-IgM syndrome type 2
