TRPM7
Description
The TRPM7 (transient receptor potential cation channel subfamily M member 7) is a protein-coding gene located on chromosome 15.
TRPM7, also known as Transient Receptor Potential cation channel, subfamily M, member 7, is a human gene that encodes a protein of the same name. TRPs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants. TRPM7 has been shown to interact with PLCB1 and PLCB2. Patients with pathogenic variants in the TRPM7 gene suffer from hypomagnesemia, seizures and developmental delay. Defects in this gene have been associated with magnesium deficiency in human microvascular endothelial cells.
TRPM7 is a crucial ion channel and serine/threonine-protein kinase that allows the passage of calcium and magnesium ions. It plays a critical role in maintaining magnesium balance within the body and regulating cell death in neurons deprived of oxygen. TRPM7 contributes to a specific type of cell death called necroptosis, triggered by TNF, by allowing calcium to enter the cell. The kinase activity of TRPM7 is essential for its function as an ion channel. This protein might be involved in a fundamental mechanism that adjusts the flow of divalent cations (like calcium and magnesium) across the cell membrane based on the cell's energy state. TRPM7 has been observed to modify the protein annexin A1 (ANXA1) by adding phosphate groups.
TRPM7 is also known as ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK.
