TROVE2
Trove2 Gene: Unraveling Its Importance in Human Health
Description:
The Trove2 gene, also known as TMEM239, is located on chromosome 11q13.3. It encodes a protein called Trove2, which stands for Transforming Growth Factor Beta Regulated VEGF C Inducer. Trove2 plays a crucial role in the regulation of angiogenesis, the formation of new blood vessels.
Associated Diseases:
Mutations or dysregulation of the Trove2 gene have been linked to several diseases, including:
- Cancer: Trove2 promotes angiogenesis, which is essential for tumor growth and metastasis. Elevated Trove2 levels have been associated with increased tumor progression in various cancers, such as breast cancer, lung cancer, and colorectal cancer.
- Cardiovascular disease: Trove2 regulates the formation of blood vessels in the heart. Dysregulation of Trove2 can contribute to the development of heart conditions such as coronary artery disease, heart failure, and myocardial infarction.
- Neurological disorders: Trove2 is involved in neurogenesis, the formation of new neurons in the brain. Mutations in Trove2 have been linked to neurodevelopmental disorders such as autism spectrum disorder and intellectual disability.
Did you Know ?
Studies have shown that high levels of Trove2 protein are associated with a 2.5-fold increased risk of developing breast cancer.
