TRIM9
Description
The TRIM9 (tripartite motif containing 9) is a protein-coding gene located on chromosome 14.
Tripartite motif-containing protein 9 (TRIM9) is a protein encoded by the TRIM9 gene in humans. It belongs to the tripartite motif (TRIM) family, characterized by three zinc-binding domains: a RING, a B-box type 1, and a B-box type 2, along with a coiled-coil region. TRIM9 is localized to cytoplasmic bodies, but its exact function remains unknown. Alternative splicing generates two transcript variants, resulting in different protein isoforms. TRIM9 has been shown to interact with SNAP-25.
TRIM9 acts as an E3 ubiquitin ligase, tagging itself for degradation via the proteasome. This process involves collaboration with the E2 enzyme UBE2D2/UBC4. TRIM9 is suggested to play a role in neuronal regulation and may be involved in the formation or breakdown of protein aggregates associated with neurodegenerative diseases. Additionally, TRIM9 might regulate synaptic vesicle release by controlling the availability of SNAP25 for SNARE complex assembly.
TRIM9 is also known as RNF91, SPRING.
Associated Diseases
- urinary bladder carcinoma
- schizencephaly
- sub-cortical nodular heterotopia
- Chudley-McCullough syndrome
- maternal uniparental disomy of chromosome 20
- mirror movements 1
- skin basal cell carcinoma
- colorectal cancer
- Parkinson disease
- glioblastoma
- ulnar-mammary syndrome
