TRIM71
Description
The TRIM71 (tripartite motif containing 71) is a protein-coding gene located on chromosome 3.
TRIM71 acts as an E3 ubiquitin ligase, collaborating with the microRNA (miRNA) machinery to enhance embryonic stem cell proliferation and maintenance. It binds to miRNAs and interacts with AGO2, participating in the post-transcriptional repression of transcripts like CDKN1A. TRIM71 also engages in post-transcriptional mRNA repression independent of miRNAs. It facilitates the G1-S transition, promoting rapid embryonic stem cell self-renewal by inhibiting CDKN1A expression. TRIM71 is crucial for maintaining proliferation and preventing premature differentiation of neural progenitor cells during early neural development. It positively regulates FGF signaling by controlling the stability of SHCBP1. TRIM71 is a specific regulator of miRNA biogenesis, binding to miRNA MIR29A hairpin and post-transcriptionally modulating MIR29A levels, which indirectly influences TET protein expression.
TRIM71 is also known as HYC4, HYDCC1, LIN-41, LIN41.
