TRIM58
Description
The TRIM58 (tripartite motif containing 58) is a protein-coding gene located on chromosome 1.
TRIM58 is an E3 ubiquitin ligase that is activated during the late stages of red blood cell development (erythropoiesis). It directly interacts with and adds ubiquitin tags to the intermediate chain of the dynein motor protein (DYNC1LI1/DYNC1LI2). This tagging leads to the breakdown of the entire dynein complex. TRIM58's role in red blood cell development is thought to involve regulating the positioning of the nucleus within the cell, which is crucial for the eventual expulsion of the nucleus from the developing red blood cell.
TRIM58 is also known as BIA2.
