TRIM50
Description
The TRIM50 (tripartite motif containing 50) is a protein-coding gene located on chromosome 7.
TRIM50 is a human gene that encodes an E3 ubiquitin ligase. It is a member of the tripartite motif (TRIM) family, also known as the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The gene is located at 7q11.23, near two homologous genes, TRIM73 and TRIM74. TRIM50 is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.
TRIM50 is an E3 ubiquitin ligase that plays a role in autophagy and inflammation. It ubiquitinates Beclin-1 in a 'Lys-63'-dependent manner, enhancing its interaction with ULK1 and promoting starvation-induced autophagy. TRIM50 also interacts with p62/SQSTM1, promoting the formation and clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Additionally, TRIM50 promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization, independent of its E3 ligase function.
TRIM50 is also known as TRIM50A.
Associated Diseases
- inflammatory bowel disease 30
- NK-cell enteropathy
- cancer
- pancreatic ductal adenocarcinoma
- Williams syndrome
