TRIM17
Description
The TRIM17 (tripartite motif containing 17) is a protein-coding gene located on chromosome 1.
TRIM17, also known as RING finger protein 16, is an E3 ubiquitin ligase that plays a crucial role in regulating various cellular processes, including neuronal apoptosis, selective autophagy, and cell proliferation. TRIM17 promotes the degradation of ZWINT, a kinetochore protein, via the proteasome pathway, thereby negatively regulating cell proliferation. Additionally, TRIM17 inhibits autophagic degradation of several target proteins while contributing to midbody autophagy. This inhibitory effect involves the interaction of TRIM17 with MCL1 and BECN1, a key regulator of autophagy. TRIM17 also controls neuronal apoptosis by mediating the ubiquitination and degradation of MCL1, leading to neuronal cell death. Furthermore, TRIM17 regulates the activity of NFAT transcription factors NFATC3 and NFATC4 by preventing their nuclear localization, inhibiting their transcriptional activity. TRIM17 also enhances alpha-synuclein/SNCA transcription by suppressing TRIM41-mediated degradation of ZSCAN2. Notably, TRIM17 inhibits the E3 ubiquitin ligase activity of TRIM28 and its interaction with BCL2A1, preventing BCL2A1 ubiquitination.
TRIM17 is also known as RBCC, RNF16, terf.
Associated Diseases
- progressive supranuclear palsy
- coxopodopatellar syndrome
- Upington disease
- hip dysplasia, Beukes type
- autosomal recessive osteopetrosis 6
- osteopathia striata-pigmentary dermopathy-white forelock syndrome
- familial clubfoot due to 17q23.1q23.2 microduplication
- multiple epiphyseal dysplasia type 5
- auriculoosteodysplasia
- spondyloepiphyseal dysplasia tarda, Kohn type
- radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome
- digitotalar dysmorphism
- metaphyseal dysplasia without hypotrichosis
- intellectual disability-spasticity-ectrodactyly syndrome
