TRIM16
Description
The TRIM16 (tripartite motif containing 16) is a protein-coding gene located on chromosome 17.
TRIM16, also known as Tripartite motif-containing protein 16, is a protein encoded by the TRIM16 gene in humans. This gene was discovered as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The TRIM16 protein contains two B box domains and a coiled-coil region characteristic of the B box zinc finger protein family. These proteins have been linked to a variety of biological processes including cell growth, differentiation, and pathogenesis. TRIM16 gene expression has been observed in most tissues, but its specific function remains unknown.
TRIM16 acts as an E3 ubiquitin ligase, playing a critical role in orchestrating the autophagic response and ubiquitination following damage to lysosomes and phagosomes. It's involved in the stress-induced formation and degradation of protein aggregates (aggresomes) by modulating the p62-KEAP1-NRF2 signaling pathway, specifically by influencing the ubiquitination levels and stability of NRF2. TRIM16 acts as a scaffold protein, facilitating the autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1, and LC3B/MAP1LC3B. This ultimately protects the cell from oxidative stress-induced cell death resulting from endomembrane damage.
TRIM16 is also known as EBBP.
