TRIAP1
Description
The TRIAP1 (TP53 regulated inhibitor of apoptosis 1) is a protein-coding gene located on chromosome 12.
TRIAP1 plays a role in regulating the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro studies have shown that the TRIAP1:PRELID1 complex facilitates the transfer of phosphatidic acid (PA) between liposomes, likely acting as a PA transporter across the mitochondrion intermembrane space to supply PA for CL synthesis within the inner membrane. Similarly, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and likely serves as a PA transporter across the mitochondrion intermembrane space (in vivo). TRIAP1 promotes cell survival by inhibiting the activation of caspase-9, thus preventing the initiation of apoptosis.
TRIAP1 is also known as HSPC132, MDM35, P53CSV, WF-1.
