TREX2
Description
The TREX2 (three prime repair exonuclease 2) is a protein-coding gene located on chromosome X.
The TREX2 gene in humans encodes an enzyme called Three prime repair exonuclease 2. This enzyme possesses 3' exonuclease activity, a characteristic shared by enzymes involved in DNA replication, repair, and recombination. Its similarity to a protein from E. coli suggests a potential role as a subunit of DNA polymerase III, which lacks intrinsic exonuclease activity.
TREX2 is an exonuclease that specifically targets double-stranded DNA with mismatched 3' ends. Its activity suggests a role in DNA repair processes.
TREX2 is also known as -.
Associated Diseases
- dermatitis herpetiformis, familial
- disseminated superficial actinic porokeratosis
- familial primary localized cutaneous amyloidosis
- hereditary leiomyomatosis and renal cell cancer
- ichthyosis, lamellar, autosomal dominant
- Dowling-Degos disease
- hyperkeratosis lenticularis perstans
- cancer
- dermatitis
