TRAF7
Description
The TRAF7 (TNF receptor associated factor 7) is a protein-coding gene located on chromosome 16.
TRAF7 acts as an E3 ubiquitin and SUMO-protein ligase, influencing various biological processes, including innate immunity, inflammation, and apoptosis. It enhances the MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators. TRAF7 negatively regulates MYB transcriptional activity by SUMOylating and sequestering it to the cytosol. It also participates in MAPK1 and MAPK3 phosphorylation, likely through interaction with MAP3K3. Importantly, TRAF7 dampens RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1, inhibiting antiviral responses. It further promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA, targeting them for lysosomal degradation and reducing NF-kappa-B transcriptional activity.
TRAF7 is also known as CAFDADD, RFWD1, RNF119.
