TRAF1
Description
The TRAF1 (TNF receptor associated factor 1) is a protein-coding gene located on chromosome 9.
TRAF1 (TNF receptor-associated factor 1) is a protein encoded by the TRAF1 gene in humans. It belongs to the TNF receptor (TNFR) associated factor (TRAF) protein family, mediating signal transduction from various TNFR superfamily receptors. TRAF1 forms a heterodimeric complex with TRAF2, essential for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with IAP, mediating anti-apoptotic signals from TNF receptors. TRAF1 expression can be induced by Epstein-Barr virus (EBV), with its LMP1 protein interacting with TRAF1 and other TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR family receptor signal transduction. Notably, TRAF1 also acts as a negative regulator of inflammation by interfering with NEMO linear ubiquitination downstream of TLR signaling, explaining the association of TRAF1 polymorphisms with increased rheumatic disease risk.
TRAF1 is an adapter molecule that plays a crucial role in regulating the activation of NF-kappa-B and JNK pathways, ultimately influencing cell survival and apoptosis. It forms a heterotrimer with TRAF2, functioning as part of an E3 ubiquitin-protein ligase complex that promotes the ubiquitination of target proteins, including MAP3K14. Notably, the TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
TRAF1 is also known as EBI6, MGC:10353.
