TRABD2A
Description
The TRABD2A (TraB domain containing 2A) is a protein-coding gene located on chromosome 2.
TRABD2A, also known as TIKI1, is a metalloprotease that functions as a negative regulator of the Wnt signaling pathway. It achieves this by cleaving the first 8 amino acids from the N-terminus of specific Wnt proteins. This cleavage event leads to the oxidation of Wnt proteins and the formation of large, inactive oligomers linked by disulfide bonds. TRABD2A has been shown to cleave WNT3A and WNT5 but not WNT11. It is essential for proper head development.
TRABD2A is also known as C2orf89, TIKI1.
