TPR
Description
The TPR (translocated promoter region, nuclear basket protein) is a protein-coding gene located on chromosome 1.
TPR is a protein that is involved in the transport of molecules between the nucleus and the cytoplasm. It is also involved in the regulation of gene expression, particularly in the control of mRNA splicing and export. In addition, TPR has been implicated in the organization of chromatin, the DNA-protein complex that makes up chromosomes.
TPR is a protein involved in the transport of molecules between the nucleus and the cytoplasm. It plays a key role in the nuclear pore complex (NPC), which acts as a gatekeeper for the movement of proteins and RNA molecules in and out of the nucleus. TPR acts as a scaffolding element within the NPC, facilitating the transport of these molecules. It is also involved in the regulation of gene expression, particularly in the control of mRNA splicing and export. In addition, TPR has been implicated in the organization of chromatin, the DNA-protein complex that makes up chromosomes. TPR is involved in the establishment of nuclear-peripheral chromatin compartmentalization in interphase and in the mitotic spindle checkpoint signaling during mitosis. It also plays a role in the quality control and retention of unspliced mRNAs in the nucleus, as well as in the export of mRNAs transcribed from heat shock gene promoters. TPR interacts with a variety of other proteins, including those involved in nuclear transport, signal transduction, and the regulation of gene expression.
TPR is also known as MRT79.
