TPM4

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Description

The TPM4 (tropomyosin 4) is a protein-coding gene located on chromosome 19.

Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.

TPM4 binds to actin filaments in both muscle and non-muscle cells. In muscle cells, it plays a critical role in the calcium-dependent regulation of striated muscle contraction, working in conjunction with the troponin complex. Smooth muscle contraction is regulated through its interaction with caldesmon. In non-muscle cells, TPM4 is involved in stabilizing cytoskeletal actin filaments. It also binds calcium.

TPM4 is also known as BDPLT25, HEL-S-108.

Associated Diseases

• Bleeding disorder, platelet-type, 25