TP53I3
Description
The TP53I3 (tumor protein p53 inducible protein 3) is a protein-coding gene located on chromosome 2.
TP53I3, the human gene encoding a putative quinone oxidoreductase, plays a role in cellular responses to oxidative stress and irradiation. The protein is similar to oxidoreductases, enzymes involved in cellular responses to oxidative stress and irradiation. TP53I3 is induced by the tumor suppressor p53 and is believed to be involved in p53-mediated cell death. The gene contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 activates TP53I3 transcriptionally by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a variable number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. This microsatellite polymorphism may be associated with differential cancer susceptibility. At least two transcript variants encoding the same protein have been found for this gene.
TP53I3 is also known as PIG3.
