TNS1
Description
The TNS1 (tensin 1) is a protein-coding gene located on chromosome 2.
Tensin-1 is a protein encoded by the TNS1 gene in humans. It localizes to focal adhesions, regions where cells attach to the extracellular matrix. Tensin-1 crosslinks actin filaments and contains a Src homology 2 (SH2) domain, often found in signal transduction molecules. It is a substrate of calpain II. Another transcript from this gene has been identified, but its full length is yet to be determined.
Tensin-1 may function as a protein phosphatase and/or a lipid phosphatase. It is involved in the formation of fibrillar adhesions, essential for myofibroblast differentiation and extracellular matrix deposition by myofibroblasts. Tensin-1 enhances RHOA activation in the presence of DLC1, and plays a role in cell polarization and migration. Additionally, it may contribute to cartilage development and link signal transduction pathways to the cytoskeleton.
TNS1 is also known as MST091, MST122, MST127, MSTP091, MSTP122, MSTP127, MXRA6, PPP1R155, TNS.
