TNR
Description
The TNR (tenascin R) is a protein-coding gene located on chromosome 1.
TNR may refer to:
Tenascin-R (TN-R) is a neural extracellular matrix (ECM) protein that interacts with various cells and matrix components, influencing cellular behavior. It can promote adhesion and differentiation or repel and inhibit neurite growth. Binding to cell surface gangliosides inhibits integrin-mediated cell adhesion, leading to decreased phosphorylation of FAK and cell detachment. Binding to sulfatides promotes oligodendrocyte adhesion and differentiation. Interaction with CNTN1 repels neurons and inhibits neurite outgrowth. Interaction with SCN2B may regulate sodium channel clustering and activity at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans interact with FN1, inhibiting cell adhesion and neurite outgrowth. The regulated addition of sulfated carbohydrates modulates TNR's adhesive properties during development and synapse maintenance.
TNR is also known as NEDSTO, TN-R.
