TNN
Description
The TNN (tenascin N) is a protein-coding gene located on chromosome 1.
TNN may refer to:
Tenascin-N (TN-N), also known as Tenascin-W, is an extracellular matrix protein that binds to integrins ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1. It is involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, it inhibits proliferation and differentiation of proteoblasts through canonical WNT signaling. In tumors, it stimulates angiogenesis by promoting the elongation, migration, and sprouting of endothelial cells. It is expressed in most mammary tumors and may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells.
TNN is also known as TN-W, TNW.
Associated Diseases
- otodental syndrome
- hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
- dentin dysplasia type I
- amelogenesis imperfecta
- splenogonadal fusion-limb defects-micrognathia syndrome
- tricho-dento-osseous syndrome
- peroxisome biogenesis disorder
