TNFSF15
Description
The TNFSF15 (TNF superfamily member 15) is a protein-coding gene located on chromosome 9.
TNFSF15, also known as VEGI and TL1A, is a protein encoded by the TNFSF15 gene in humans. It plays a role in inhibiting the formation of new blood vessels (angiogenesis). TNFSF15 is a member of the tumor necrosis factor (TNF) ligand family, and it interacts specifically with the death receptor 3 (TNFRSF25) and decoy receptor 3 (TNFRSF6B). Its expression is stimulated by TNF-alpha and IL-1 alpha, and it primarily resides in endothelial cells. TNFSF15 can activate both the NF-κB and MAPK signaling pathways, and it induces cell death (apoptosis) in endothelial cells. This makes it an important factor in controlling blood vessel formation.
This protein interacts with the receptors TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It triggers the activation of NF-kappa-B. TNFSF15 inhibits vascular endothelial cell growth and angiogenesis in lab settings, and promotes the activation of caspases, leading to cell death.
TNFSF15 is also known as TL1, TL1A, TNLG1B, VEGI, VEGI192A.
