TNFRSF25

Description

The TNFRSF25 (TNF receptor superfamily member 25) is a protein-coding gene located on chromosome 1.

TNFRSF25, also known as Death receptor 3 (DR3), is a cell surface receptor of the tumor necrosis factor receptor superfamily that mediates apoptotic signaling and differentiation. Its only known TNFSF ligand is TL1A (TNFSF15). TNFRSF25 is preferentially expressed by activated and antigen-experienced T lymphocytes, and is also highly expressed by FoxP3 positive regulatory T lymphocytes. It is activated by TL1A, which is rapidly upregulated in antigen presenting cells and some endothelial cells following Toll-Like Receptor or Fc receptor activation. TNFRSF25 signals through the TRADD adaptor molecule to stimulate NF-kappa B activity or through the FADD adaptor molecule to stimulate caspase activation and regulate cell apoptosis. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. Specifically, activation of TNFRSF25 is dependent upon previous engagement of the T cell receptor.

TNFRSF25 is also known as APO-3, DDR3, DR3, GEF720, LARD, PLEKHG5, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing