TMEM8B
Description
The TMEM8B (transmembrane protein 8B) is a protein-coding gene located on chromosome 9.
TMEM8B is a gene that encodes for a transmembrane protein in humans. This protein is 338 amino acids long and is located on chromosome 9. Other names for this gene include C9orf127, NAG-5, and NGX61. It is located on chromosome 9, spanning from base pair 35,814,451 to 35,865,518 and containing 19 exons. There are 13 transcript variants that encode proteins, with the longest being 790 amino acids long. TMEM8B expression varies across 32 human tissues, with highest levels found in the brain, ovaries, prostate, placenta, and pancreas. Expression is downregulated in some cancers, particularly nasopharyngeal and colorectal carcinomas. TMEM8B is expressed throughout development, including fetal stages, with low levels detected in the fetal liver, brain, and thymus.
TMEM8B may regulate the EGFR pathway. It is a probable tumor suppressor, potentially playing a role in cell growth, proliferation, and adhesion. These functions are supported by evidence from several studies (PubMed: 15498789, 15723283, 17270023, 17641538).
TMEM8B is also known as C9orf127, FP588, LINC00950, NAG-5, NAG5, NGX6, NGX6a.
