TMEM88
Description
The TMEM88 (transmembrane protein 88) is a protein-coding gene located on chromosome 17.
TMEM88 plays a critical role in heart development by suppressing the Wnt/beta-catenin signaling pathway. It acts downstream of GATA factors in the pre-cardiac mesoderm, guiding the development of cardiomyocytes.
TMEM88 is also known as -.
Associated Diseases
- Gollop-Wolfgang complex
- tibial hemimelia
- tibia, hypoplasia or aplasia of, with polydactyly
- fibular aplasia-ectrodactyly syndrome
- Blount disease
- metaphyseal anadysplasia
