TMEM86A
Description
The TMEM86A (transmembrane protein 86A) is a protein-coding gene located on chromosome 11.
TMEM86A is an enzyme that breaks down a type of lipid called lysoplasmalogen. Specifically, it breaks the vinyl ether bond in these lipids, releasing fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine. This activity is specific to the lyso form of plasmalogen, meaning it only acts on plasmalogens that have lost a fatty acid at the sn-2 position. TMEM86A is involved in the metabolism of lysoplasmalogens in fat cells (adipocytes) and macrophages.
TMEM86A is also known as -.
Associated Diseases
- alcohol dependence
- Gollop-Wolfgang complex
- tibial hemimelia
- tibia, hypoplasia or aplasia of, with polydactyly
- fibular aplasia-ectrodactyly syndrome
- Blount disease
- metaphyseal anadysplasia
- acromesomelic dysplasia 2B
- brachydactyly-preaxial hallux varus syndrome
- acheiropody
- syndactyly type 4
- laurin-Sandrow syndrome
- acromesomelic dysplasia 2C, Hunter-Thompson type
- spondyloepimetaphyseal dysplasia, Missouri type
- patella aplasia/hypoplasia
- fibular dimelia-diplopodia syndrome
- acromesomelic dysplasia 2A
- mesomelic dysplasia, Savarirayan type
