TMEM74
Description
The TMEM74 (transmembrane protein 74) is a protein-coding gene located on chromosome 8.
TMEM74 plays a crucial role in the process of autophagy, a cellular mechanism for breaking down and recycling damaged or unnecessary components. The activation of autophagy by TMEM74 likely involves the PI3K signaling pathway.
TMEM74 is also known as NET36.
Associated Diseases
- 46,XY complete gonadal dysgenesis
- 46,XX ovotesticular disorder of sex development
- 46,XX testicular disorder of sex development
- testicular agenesis
- tetragametic chimerism
- gonadoblastoma
- Mayer-Rokitansky-Kuster-Hauser syndrome
- immunodeficiency 75
- glycoprotein storage disease
- hemoglobin H disease
- cancer
