TMEM65


Description

The TMEM65 (transmembrane protein 65) is a protein-coding gene located on chromosome 8.

TMEM65 is essential for maintaining proper cardiac intercalated disk (ICD) structure and function as well as cardiac conduction velocity in the heart. Association with SCN1B is required for stabilizing the perinexus in the ICD and for localizing GJA1 and SCN5A to the ICD. TMEM65 may regulate the function of the gap junction protein GJA1 and contribute to its stability and proper localization to the cardiac intercalated disk, thereby regulating gap junction communication. Additionally, TMEM65 may play a role in regulating mitochondrial respiration and mitochondrial DNA copy number maintenance.

TMEM65 is also known as -.

Associated Diseases



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