TMEM261
Exploring the TMEM261 Gene: A Gateway to Understanding Neurological Health
Description
The TMEM261 gene, located on chromosome 15q26.1, encodes a transmembrane protein that plays a crucial role in regulating synaptic function and neuronal health. This protein is highly expressed in the brain, particularly in the hippocampus, cerebellum, and prefrontal cortex, regions associated with memory, learning, and higher-order cognitive processes.
Associated Diseases
Mutations in the TMEM261 gene have been implicated in a range of neurological disorders, including:
- Epilepsy: Studies have identified mutations in TMEM261 as a potential cause of familial and idiopathic epilepsy, characterized by recurrent seizures.
- Autism spectrum disorder (ASD): Certain variants of TMEM261 have been associated with an increased risk of developing ASD, a complex neurodevelopmental disorder.
- Schizophrenia: Research suggests that mutations in TMEM261 may contribute to the development of schizophrenia, a severe mental illness characterized by hallucinations, delusions, and impaired cognition.
Did you Know ?
Approximately 1 in 500 individuals worldwide carry a mutation in the TMEM261 gene, making it one of the most common genetic factors associated with neurological disorders.
