TMEM258
Description
The TMEM258 (transmembrane protein 258) is a protein-coding gene located on chromosome 11.
TMEM258, also known as Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TMEM258, is a subunit of the oligosaccharyl transferase (OST) complex. This complex catalyzes the initial transfer of a specific glycan, Glc(3)Man(9)GlcNAc(2), from a lipid carrier, dolichol-pyrophosphate, to an asparagine residue within a specific sequence motif (Asn-X-Ser/Thr) in newly synthesized protein chains. This process, known as N-glycosylation, occurs while the protein is being made (cotranslationally). The OST complex associates with the Sec61 complex, a channel-forming complex that helps proteins move across the endoplasmic reticulum (ER) membrane. All subunits of the OST complex are necessary for its full activity. TMEM258 is also involved in maintaining the stability of the ER in the lining of the colon.
TMEM258 is also known as C11orf10, Kud, Kuduk.
