TMEM201
Description
The TMEM201 (transmembrane protein 201) is a protein-coding gene located on chromosome 1.
TMEM201 plays a role in the movement of the nucleus during fibroblast polarization and migration. It is thought to be involved in actin-dependent nuclear movement through its association with transmembrane actin-associated nuclear (TAN) lines, which are linked to F-actin cables and connect the nucleus to retrograde actin flow. Overexpression of TMEM201 can recruit Ran GTPase to the nuclear periphery.
TMEM201 is also known as Ima1, NET5, SAMP1.
Associated Diseases
- glomerulosclerosis
- Crohn ileitis
- exudative vitreoretinopathy 2, X-linked
- Emery-Dreifuss muscular dystrophy
- hemophagocytic syndrome
- autoimmune gastritis
- interstitial nephritis
