TMEM19
Description
The TMEM19 (transmembrane protein 19) is a protein-coding gene located on chromosome 12.
The TMEM19 gene is located on chromosome 12 (12q21.1), spanning 18,966 base pairs on the + strand. It contains 6 exons. The mRNA transcript of TMEM19 is 5662 base pairs long. Studies have shown that TMEM19 is involved in ammonia nitrogen tolerance and is a risk factor for non-syndromic cleft lip with palate (NSCLP). TMEM19 is expressed in most tissues but shows increased expression in the duodenum, kidney, skin, small intestine, and urinary bladder. In a non-alcoholic fatty liver disease (NAFLD) model, TMEM19 expression was found to be involved in cell death due to excessive disulfide formation in the actin cytoskeleton.
TMEM19 is associated with ammonia nitrogen tolerance and has been identified as a risk factor for non-syndromic cleft lip with palate (NSCLP). It is expressed in most tissues but shows increased expression in the duodenum, kidney, skin, small intestine, and urinary bladder. In a non-alcoholic fatty liver disease (NAFLD) model, TMEM19 expression was found to be involved in cell death due to excessive disulfide formation in the actin cytoskeleton.
TMEM19 is also known as -.
