TMEM178A
Description
The TMEM178A (transmembrane protein 178A) is a protein-coding gene located on chromosome 2.
TMEM178A acts as a negative regulator of osteoclast differentiation, impacting both normal and inflammatory states. It achieves this by influencing calcium ion flow triggered by TNFSF11, ultimately controlling the activation of NFATC1.
TMEM178A is also known as TMEM178.
Associated Diseases
- Kallmann syndrome
- melorheostosis
- familial avascular necrosis of femoral head
- acroosteolysis
- talo-patello-scaphoid osteolysis
- dacryocystitis-osteopoikilosis syndrome
- osteomesopyknosis
- 12q14 microdeletion syndrome
- osteopenia-intellectual disability-sparse hair syndrome
