TMEM171
Description
The TMEM171 (transmembrane protein 171) is a protein-coding gene located on chromosome 5.
TMEM171 is a protein encoded by the TMEM171 gene in humans. It is also known as PRP2 or proline-rich protein 2. The gene spans 11,526 base pairs and contains 4 exons. It is located on chromosome 5, specifically on the long arm at 5q13.2. The promoter region is 2034 base pairs long and extends beyond the first exon. Transcription factors predicted to bind to the promoter region include p63 tumor protein, CCCTC binding factors, TATA binding factors, and thyroid hormone receptors. TMEM171 exhibits moderate and variable expression across various tissues, with the highest levels observed in the thyroid, mammary gland, stomach, duodenum, and kidney. It is also expressed at moderate levels in tissues such as the spleen, ileum, colon, and salivary gland, and at lower levels in other tissues.
The exact function of TMEM171 is currently unknown. It is a transmembrane protein, meaning it spans the cell membrane, suggesting a role in cell signaling or transport. However, its moderate and varied expression across different tissues, including the thyroid, mammary gland, stomach, duodenum, and kidney, indicates it may have a broader role in cellular processes. Its promoter region suggests the involvement of various transcription factors, like p63 tumor protein, CCCTC binding factors, and TATA binding factors, in its regulation.
TMEM171 is also known as PRP2.
