TMEM14B
Description
The TMEM14B (transmembrane protein 14B) is a protein-coding gene located on chromosome 6.
TMEM14B is a primate-specific protein that plays a crucial role in the development of the neocortex, specifically contributing to its expansion and folding. It is believed to promote the proliferation of neural progenitor cells by facilitating the nuclear translocation of IQGAP1, a protein involved in cell cycle regulation. This translocation, in turn, promotes the transition from the G1 phase to the S phase of the cell cycle.
TMEM14B is also known as -.
Associated Diseases
- benign neoplasm of parathyroid gland
- hemoglobin D disease
- dominant beta-thalassemia
- hemoglobin H disease
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin E disease
- dehydrated hereditary stomatocytosis
- hemoglobin C-beta-thalassemia syndrome
- X-linked sideroblastic anemia 1
- hemoglobin E-beta-thalassemia syndrome
- delta-beta-thalassemia
- cyanosis, transient neonatal
- alpha-thalassemia-myelodysplastic syndrome
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome
- beta-thalassemia-X-linked thrombocytopenia syndrome
- microcytic anemia with liver iron overload
- Heinz body anemia
- sideroblastic anemia 3
