TMEM143
Description
The TMEM143 (transmembrane protein 143) is a protein-coding gene located on chromosome 19.
TMEM143 (Transmembrane protein 143) is a protein encoded by the TMEM143 gene in humans. It is a dual-pass protein, meaning it has two transmembrane domains, and is predicted to be located in the mitochondria. The gene is located on chromosome 19 and has five transcript variants. The longest transcript, variant 1, encodes the longest protein isoform, isoform a, which is 459 amino acids long with a molecular weight of 51.6 kDa and an isoelectric point of 9.7. The other transcript variants encode shorter isoforms that lack some of the exons found in variant 1, resulting in N-terminally truncated proteins. TMEM143 has been shown to have high expression in both human skeletal muscle and the heart. Interaction with other proteins suggests that TMEM143 could potentially play a role in tumor suppression/expression and cancer regulation.
TMEM143 is also known as -.
