TMEM108
Description
The TMEM108 (transmembrane protein 108) is a protein-coding gene located on chromosome 3.
TMEM108 is a transmembrane protein crucial for proper cognitive function. It plays a vital role in the development of dentate gyrus (DG) neuron circuitry, ensuring the surface expression of AMPA receptors and proper excitatory postsynaptic currents in DG granule neurons. Additionally, TMEM108 regulates the organization and stability of the microtubule network in sensory neurons, facilitating axonal transport. Through its interaction with DST, it mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, TMEM108 is essential for BDNF-dependent dendrite outgrowth. It collaborates with SH3GL2 to recruit the WAVE1 complex, promoting actin-dependent BDNF:NTRK2 early endocytic trafficking and signal transduction from early endosomes.
TMEM108 is also known as CT124, RTLN.
Associated Diseases
- bipolar disorder
- lattice corneal dystrophy type I
- psychiatric disorder
- schizophrenia
- major depressive disorder
