TMEM106C
Description
The TMEM106C (transmembrane protein 106C) is a protein-coding gene located on chromosome 12.
TMEM106C is a gene that encodes the transmembrane protein 106C (TMEM106C) in Homo sapiens. It has been found to be overexpressed in cancer cells and is also related to distal arthrogryposis, a condition of stiff joints and irregular muscle development. The TMEM106C gene contains a domain of unknown function, DUF1356, that spans most of the protein. Transmembrane protein 106C also goes by the aliases MGC5576 or MGC111210, LOC79022.
== Location and gene neighborhood == The TMEM106C gene is located on the long arm of the 12th chromosome. It is found at position 12q13.1. This gene spans from 48357225 to 48362667 on chromosome 12. This gene is in between COL2A1, the human type II collagen gene, and VDR, the human Vitamin D Receptor gene. This protein is found to be an integral part of the endoplasm reticulum membrane.
== Protein structure == The TMEM106A protein has a molecular weight of 27.9 kdal with a PI of 6.325. It has 250 amino acids, 230 of which are in the domain of unknown function.
TMEM106C is also known as -.
