TLK1
Description
The TLK1 (tousled like kinase 1) is a protein-coding gene located on chromosome 2.
TLK1 (Tousled-like kinase 1) is an enzyme encoded by the TLK1 gene in humans. It is a nuclear serine/threonine kinase that belongs to the Tousled-like kinase family, first identified in Arabidopsis. TLK1 is potentially involved in regulating chromatin assembly. TLK1 has been shown to interact with ASF1B, ASF1A, and TLK2.
TLK1 is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This inhibition is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 of TLK1 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, TLK1 phosphorylates histone H3 at 'Ser-10'.
TLK1 is also known as PKU-beta.
