TLE4
Description
The TLE4 (TLE family member 4, transcriptional corepressor) is a protein-coding gene located on chromosome 9.
Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene. TLE4 has been shown to interact with PAX5.
TLE4 acts as a transcriptional corepressor, binding to various transcription factors. It inhibits the activation of transcription by PAX5, CTNNB1, and TCF family members involved in Wnt signaling. Full-length TLE proteins can be regulated by interactions with dominant-negative AES. TLE4 is crucial for the repressor activity of SIX3 during eye development, including retina and lens formation, and for SIX3's self-repression. It participates in repressing GNRHR transcription and enhances the suppression of CGA/alpha-GSU by MSX1.
TLE4 is also known as BCE-1, BCE1, E(spI), E(spl), ESG, ESG4, GRG4, Grg-4.
