TIPIN
Description
The TIPIN (TIMELESS interacting protein) is a protein-coding gene located on chromosome 15.
TIPIN (TIMELESS-interacting protein) is a protein encoded by the TIPIN gene in humans. TIPIN interacts with Replication protein A1.
TIPIN plays a crucial role in regulating DNA replication and maintaining the stability of replication forks, ensuring proper DNA duplication. It's vital for cell survival when DNA damage or replication stress occurs, potentially by activating the ATR-CHEK1 pathway in response to specific DNA-damaging agents like hydroxyurea or UV light. TIPIN interacts with TIMELESS, forming a complex that influences DNA replication under normal and stressful conditions. This complex contributes to replication fork stability and modulates CHEK1 phosphorylation and the intra-S phase checkpoint, crucial for responding to genotoxic stress.
TIPIN is also known as -.
