TIGIT
Description
The TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a protein-coding gene located on chromosome 3.
TIGIT (T cell immunoreceptor with Ig and ITIM domains), also known as WUCAM and Vstm3, is an immune receptor present on some T cells and natural killer cells (NK). It binds to CD155 (PVR) on dendritic cells (DCs), macrophages, etc. with high affinity, and also to CD112 (PVRL2) with lower affinity. Clinical trials on TIGIT-blockade in cancer are ongoing, showing promise for combined TIGIT and PD-L1 co-blockade in solid cancer patients. Mechanistically, TIGIT-Fc fusion protein could interact with PVR on dendritic cells, increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation in vivo. TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain. TIGIT regulates T-cell mediated immunity via the CD226/TIGIT-PVR pathway. During HIV infection, TIGIT expressing CD8+ T cells have been shown to be expanded and associated with clinical markers of HIV disease progression.
TIGIT is also known as VSIG9, VSTM3, WUCAM.
