THRAP3
Description
The THRAP3 (thyroid hormone receptor associated protein 3) is a protein-coding gene located on chromosome 1.
Thyroid hormone receptor-associated protein 3 is a protein that in humans is encoded by the THRAP3 gene.
THRAP3 is involved in pre-mRNA splicing and remains associated with spliced mRNA, likely through interactions with the exon junction complex (EJC). It can trigger mRNA decay, seemingly independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. THRAP3 may also participate in nuclear mRNA decay and regulation of signal-induced alternative splicing. During PTPRC/CD45 splicing, it's proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. THRAP3 contributes to cyclin-D1/CCND1 mRNA stability, potentially by acting as a component of the SNARP complex, which associates with both the 3' end of the CCND1 gene and its mRNA. It's implicated in the response to DNA damage, being excluded from DNA damage sites in a manner similar to transcription inhibition; this function might involve the SNARP complex. Initially considered a transcriptional coactivator through its association with the TRAP complex, THRAP3 is not considered a stable Mediator complex subunit. Working with HELZ2, it enhances PPARG-mediated transcriptional activation, possibly by stabilizing PPARG binding to DNA in the presence of a ligand. THRAP3 may play a role in the terminal stage of adipocyte differentiation. It's involved in the positive regulation of the circadian clock, acting as a coactivator of the CLOCK-BMAL1 heterodimer, promoting its transcriptional activator activity and binding to circadian target genes (PubMed:24043798). (ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:20932480, ECO:0000269|PubMed:22424773, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:24043798)
THRAP3 is also known as BCLAF2, TRAP150.
