THOC2
Description
The THOC2 (THO complex subunit 2) is a protein-coding gene located on chromosome X.
THO complex subunit 2 is a protein that in humans is encoded by the THOC2 gene.
THOC2 is crucial for the efficient export of polyadenylated and spliced messenger RNA (mRNA) from the nucleus to the cytoplasm. It acts as a subunit of the THO subcomplex, part of the larger TREX complex, which is involved in linking mRNA transcription, processing, and nuclear export. The TREX complex preferentially associates with spliced mRNA and is recruited to these molecules independently of transcription. It binds to mRNA upstream of the exon-junction complex (EJC) and is recruited to the 5' end of the mRNA in a manner dependent on splicing and the 5' cap. THOC2, along with the THO complex, is involved in the release of mRNA from nuclear speckle domains and is required for the proper localization of NXF1, a key protein involved in nuclear export, to the nuclear rim. THOC2 is also essential for proper neuronal development. The TREX complex plays a crucial role in exporting Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and is required for the production of infectious KSHV.
THOC2 is also known as CXorf3, MRX12, MRX35, THO2, XLID12, dJ506G2.1, hTREX120.
Associated Diseases
- Mental retardation, X-linked 12/35
- X-linked intellectual disability-short stature-overweight syndrome
