THBS1
Description
The THBS1 (thrombospondin 1) is a protein-coding gene located on chromosome 15.
THBS1 encodes thrombospondin-1, a protein that is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It can bind to fibrinogen, fibronectin, laminin, collagens types V and VII, and integrins alpha-V/beta-1. THBS1 plays roles in platelet aggregation, angiogenesis, and tumorigenesis. THBS1 is a member of the thrombospondin family and is a natural inhibitor of neovascularization and tumorigenesis. It interacts with at least 12 cell adhesion receptors, including CD36, αv integrins, β1 integrins, syndecan, and integrin-associated protein (IAP or CD47), and numerous proteases involved in angiogenesis.
THBS1, also known as thrombospondin-1 or glycoprotein G, is a multifunctional protein that plays a crucial role in various cellular processes. It acts as an adhesive glycoprotein, mediating interactions between cells and the extracellular matrix. THBS1 is involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. THBS1 negatively regulates dendritic cell activation and cytokine release, contributing to the resolution of inflammation and immune homeostasis. THBS1 interacts with receptors CD47 and CD36, modulating NO signaling, promoting endothelial cell senescence, inhibiting stem cell self-renewal, and suppressing angiogenesis. THBS1 also interacts with SIRPA, contributing to ROS signaling in non-phagocytic cells. It may play a role in metabolic dysfunction in diet-induced obesity and ER stress response. THBS1's involvement in age-related conditions, including metabolic dysregulation, during normal aging has also been suggested.
THBS1 is also known as THBS, THBS-1, TSP, TSP-1, TSP1.
