TFCP2L1
Description
The TFCP2L1 (transcription factor CP2 like 1) is a protein-coding gene located on chromosome 2.
TFCP2L1 is a transcription factor that plays a critical role in maintaining pluripotency in embryonic stem cells (ESCs). It acts in conjunction with KLF2 to mediate the induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling. TFCP2L1 is also essential for normal duct development in the salivary gland and kidney. It coordinates the development of kidney collecting ducts, regulating the expression of genes involved in acid-base and salt-water homeostasis. Specifically, TFCP2L1 regulates the expression of genes in intercalated (IC) cells, including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6, and the IC-specific transcription factor FOXI1. Additionally, TFCP2L1 regulates the expression of JAG1 and subsequent notch signaling in the collecting duct. Notably, JAG1 initiates notch signaling in principal (PC) cells but inhibits notch signaling in ICs. TFCP2L1 functions as a transcriptional suppressor, potentially suppressing UBP1-mediated transcriptional activation. It also modulates the placental expression of CYP11A1.
TFCP2L1 is also known as CRTR1, LBP-9, LBP9.
