TEN1
Description
The TEN1 (TEN1 subunit of CST complex) is a protein-coding gene located on chromosome 17.
The TEN1 protein is part of the CST complex, which acts as a specialized replication factor that facilitates DNA replication during challenging situations, such as when replication stress is present or natural barriers like telomeres are encountered. The CST complex exhibits a strong affinity for single-stranded DNA, irrespective of its sequence, while individual subunits demonstrate a weak DNA binding capacity. Initially, the CST complex was thought to safeguard telomeres against degradation. However, subsequent research has revealed its involvement in various aspects of telomere replication. The CST complex is known to inhibit telomerase activity and play a role in regulating telomere length. It is believed to bind to newly synthesized telomere 3' overhangs, terminating telomerase activity. This process likely involves interaction with the ACD:POT1 complex, ultimately hindering telomerase stimulation. Furthermore, the CST complex is thought to participate in the filling-in of the telomeric C-strand, potentially through recruitment and activation of DNA polymerase alpha. The CST complex also contributes to the recovery process following various forms of external DNA damage. It appears to be involved in re-initiating DNA replication at repaired replication forks or dormant origins.
TEN1 is also known as C17orf106.
Associated Diseases
- peroxisomal acyl-CoA oxidase deficiency
- cancer
- pachyonychia congenita
- metastatic malignant neoplasm
- Coats plus syndrome
