TEAD2
Description
The TEAD2 (TEA domain transcription factor 2) is a protein-coding gene located on chromosome 19.
TEAD2 (ETF, ETEF-1, TEF-4) belongs to a family of transcription factors called the TEAD family, which are highly conserved across species. It is expressed in a subset of embryonic tissues, including the cerebellum, testis, and limb buds. TEAD2 is less studied than TEAD1, but research has revealed its role in development. TEAD2, like other members of the family, contains the TEA/ATTS DNA-binding domain. The family includes TEAD1, TEAD2, TEAD3, and TEAD4 in mammals.
TEAD2 is a transcription factor that plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression. It regulates cell proliferation, migration, and epithelial mesenchymal transition (EMT) by mediating gene expression of YAP1 and WWTR1/TAZ. TEAD2 binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and may be involved in the gene regulation of neural development. It also binds to the M-CAT motif.
TEAD2 is also known as ETF, TEAD-2, TEF-4, TEF4.
Associated Diseases
- isolated spina bifida
- anencephaly 1
- spina bifida-hypospadias syndrome
- systemic lupus erythematosus
- multiple sclerosis
- cancer
- multiple acyl-CoA dehydrogenase deficiency
- breast cancer
- osteopathia striata with cranial sclerosis
